A pooled analysis investigated the prognostic role of DNA mismatch repair status in patients with stage III colon cancer treated with a standard adjuvant chemotherapy regimen. READ MORE
Quality metrics may not lead to better overall survival in patients with surgically resected stage 3 colon cancer.
Research in Review
Short-course preoperative radiotherapy combined with delayed surgery reduces the adverse effects of rectal cancer surgery while maintaining its efficiency, according to a study published in The Lancet (published online February 9, 2017; doi: 10.1016/S1470-2045(17)30086-4).
Chemotherapy may be overused among young and middle-aged patients with colon cancer.
The addition of BRAF-inhibitor vemurafenib to irinotecan and cetuximab chemotherapy treatment improves progression-free survival.
Nivolumab has shown disease control in pretreated patients with DNA mismatch repair deficient/microsatellite instability high metastatic colorectal cancer.