By Marilynn Larkin

NEW YORK (Reuters Health) – Adding external beam radiation therapy (EBRT) to radioactive iodine (RAI) leads to good disease control in locally advanced, differentiated thyroid cancer, especially for patients with tracheal or esophageal invasion who received aggressive surgical resection, researchers say

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News

By Marilynn Larkin

NEW YORK (Reuters Health) – Adding external beam radiation therapy (EBRT) to radioactive iodine (RAI) leads to good disease control in locally advanced, differentiated thyroid cancer, especially for patients with tracheal or esophageal invasion who received aggressive surgical resection, researchers say

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For patients with oropharyngeal squamous cell carcinoma receiving transoral robotic surgery, adjuvant radiotherapy or chemoradiotherapy should be avoided if possible, according to a long-term functional and quality-of-life outcomes study.

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Although patients with HPV-positive oropharyngeal squamous cell carcinoma generally have a more favorable prognosis than patients with HPV-negative disease, those with perineural invasion or angiolymphatic invasion and stage II disease may have poorer outcomes.

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Patients with a non-thyroid cancer who experience hypothyroidism during cancer treatment with a TKI benefit from significantly increased survival compared with those who have normal thyroid function.

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Research in Review

A recent study suggests that immunotherapies targeting both PD-L1 and PD-L2 may enhance response rates for patients with head and neck squamous cell carcinoma.

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Although HPV vaccine reduces the rate of oral HPV infection, the vaccine is still underutilized among teens and young adults. 

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PD-L1 expression may be a biomarker of local failure in human papillomavirus (HPV)-negative head and neck squamous cell carcinoma following radiotherapy.

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Patients aged 80 years or older with early-stage esophageal cancer who received treatment had an increased 5-year overall survival compared with those who received no treatment or observation alone.

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Resources

The National Comprehensive Cancer Network has updated their guidelines for central nervous system cancers to include new systemic therapies for the treatment of brain metastases.

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Conferences

Clinical trial results have shown that treatment with nivolumab may be the best choice for patients with head and neck cancer. 

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